The discovery of stem cells in the adult brain has generated a great deal of excitement in the neurosciences. Thousands of new cells are produced each day in a healthy hippocampus, a key brain area for learning and memory. However, soon after the cells are born, many of them die unless they are exposed to a learning experience. Thus, new neurons in the adult are rescued from death by learning. With this award, a number of important questions about the relationship between learning and neurogenesis will be answered: What do new neurons do once they are rescued from death? Are they used for memory or for acquiring new information? Are new cells retained with each new learning experience and if so, do they then contribute to learning in the future? Also, do the absolute numbers that are born relate to the numbers kept alive by learning? And finally, what physiological mechanisms and brain rhythms keep them alive? To answer these questions, behavioral, electrophysiological, molecular and biochemical techniques will be used. These studies are important because they will identify the critical features of learning that keep new neurons alive and in turn how those new neurons then contribute to optimal learning in the future. The discovery of neurogenesis has transformed the way we think about the adult brain and generated much interest in the public, especially educators of children and young adults. These findings will be disseminated to the public with writings in lay magazines (i.e. Shors, Scientific American, 2009) and public presentations (i.e. Quark Park, a public art installation about science). The project will train postdoctoral, graduate and undergraduate students in this new field of research which intersects biology, psychology, physiology, as well as biomedical and stem cell engineering.

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As the working hours get longer and as communication scientific knowledge improves, folks are socially communicating less. We are just awfully busy to make new friends let alone construct authentically meaningful bond. At the end of the day, who needs face to face communication when you could do it in Twitter, Facebook and the numerous online talking services?

This seclusion trend is unfortunate at best because your brain, in addition to brain food, craves social interaction to function at its top. So critical is that it is on our health that a few specialist in the field believe that the amount of social interaction an individual had is one of the golden guide of health and independence in an individual’s old age.

How come social interactions so essential to a healthy brain?

Because your brain is able of neurogenesis (the procedure of developing brand new brain cells). Nevertheless neurogenesis results only when you sufficiently challenge your brain.

Well, communicating with other individual is one of the ultimate challenging task that an individual can take on. As Lawrence Katz once said, “There is a lot of evidences that another person is the ultimate in uncertain things you can encounter. So activities that have you communicating with another human beings is an awesome way of brain exercise.”

As you turn into more isolated, you are thus using less of your brain. As reported by Hebbian Learning principles, you lost what you don’t use. Thus brain cells die off and synapses breaks down as you grow older.

Unfortunately, people who are older also tend to live a more lonely life – thus starting a vicious cycle of mental decline. Sure, making new friends can be challenging and as any worthwhile relationships, you require plentiful energy to make it extraordinary.

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LONDON – Scientists have discovered a new source for the generation of nerve cells in the brain.

Professor Magdalena Gotz of Helmholtz Zentrum Munchen and Ludwig-Maximilians-Universitat (LMU) Munich and colleagues have discovered progenitor cells, which can form new glutamatergic neurons following injury to the cerebral cortex.

Particularly in Alzheimer’s disease, nerve cell degeneration plays a crucial role. In the future, new therapeutic options may possibly be derived from steering the generation and/or migration mechanism, according to the researchers.

Until only a few years ago, neurogenesis – the process of nerve cell development – was considered to be impossible in the adult brain.

Then researchers discovered regions in the forebrain in humans in which new nerve cells can be generated throughout life. These so-called GABAergic cells use gamma-aminobutyric acid (GABA), a neurotransmitter of the central nervous system.

Now, the research team, led by Gotz, has taken a closer look at this brain region in the mouse model. They found that even in the forebrain, there are other nerve cells that are regularly generated – the so-called glutamatergic nerve cells, which use glutamate as neurotransmitter.

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The idea that the adult brain changes with experience was once a radical idea, but it is now well accepted that certain areas—say, the motor cortex, when learning a new physical skill—can grow new neurons or create stronger connections.

Now scientists report that the brain is even more mutable than suspected. Thanks to an unconventional research technique, neuroscientists have found the first physical proof that new experiences and information have wide-ranging effects throughout both hemispheres of the brain, rather than just creating connections in one discrete area.

“We have learned that what we call neuronal plasticity isn’t exclusive to individual synapses or even the neurons where they contact but rather occurs throughout the functional network in which synapses and neurons are embedded,” Canals says. “Those networks are absent in brain slices, so they couldn’t be studied before.”

By showing how activity in the hippocampus causes widespread changes in brain structure, Canals says the findings could explain why new memories are at first dependent on the hippocampus but can eventually be recalled without triggering that part of the brain at all.

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They say you can’t teach an old dog new tricks, but scientific findings seem to indicate otherwise. Research shows that our brains literally rewire in response to new stimulation. And when it comes to computer use, Internet activity may stimulate and possibly improve brain function, according to scientists at UCLA.

“Technology may be changing our minds and changing the way we think,” said Dr. Gary Small, a neuroscientist speaking last month at the UCLA Technology & Aging Conference at the Skirball Cultural Center.

Small, director of the UCLA Center on Aging, described results of research he and colleagues performed with volunteers between the ages of 55 and 76. Half of the participants were familiar with how to search the Internet, and the other half were new to it. The participants engaged in Internet searching while simultaneously undergoing functional magnetic resonance imaging (MRI).

The MRI images clearly showed activity in the areas of the brain that control decision-making and complex reasoning — but only in the Web-savvy group. The inexperienced group showed no such activity.

However, after just five one-hour sessions of practice, the Web newbies showed activation in the same areas of the brain as the savvy group.

“Five hours on the Internet and the naive subjects had already rewired their brains,” said Small, writing about the findings in “iBrain: Surviving the Technological Alteration of the Modern Mind” (HarperCollins). “Recent studies demonstrate that older brains do remain malleable and plastic throughout life. Even areas of the brain that were reserved for specialized tasks can be recruited and retrained.”

In other words, “use it or lose it” applies to the brain. Indeed, Small notes, “Several studies have shown that exercising the brain with mental aerobics not only can improve cognitive performance scores but also may delay brain degeneration.”

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Through the brain-imaging work at the Amen Clinics during the past 20 years with tens of thousands of people from 75 different countries, we have come to see that when your brain works right, you tend to be more thoughtful, playful, romantic, intimate, committed, and loving with your partner — all necessary things for great relationships.

When your brain has trouble, you are much more likely to be impulsive, distracted, addicted, unfaithful, angry, and even hateful — all things that undermine relationships.

Even though it feels genital, the vast majority of love and sex occurs in the brain. Your brain decides who is attractive to you, how to get a date, how well you do on a date, what to do with the feelings that develop, how long those feelings last, when to commit, and how well you do as a partner and parent. Your brain helps you be enthusiastic in the bedroom or drains you of desire and passion. Your brain helps you process and learn from a breakup or makes you vulnerable to depression or obsession.

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The ability of humans to learn, remember, and adapt is directly related to the changeableness (plasticity) of the human brain. Whenever we learn new information, the connections between nerve cells in the brain are modified. The activity of some connections (called synapses) increases, while the activity of other synapses decreases. The initial changes involve local chemical alterations in the way synapses transmit and receive information from other neurons. These initial chemical changes eventually lead to structural changes in the brain; that is, more connections and more complex connections form. The longer lasting of these changes require the turning on and turning off of specific genes; therefore, learning involves gene expression. Changes in synaptic connections represent a major way by which memories are formed. But some memories fade, and it is likely that the newly formed connections must be reinforced by ongoing brain activity in order for these connections to survive. The important points to remember are that learning alters the actual structure of the brain and that genes are involved in learning.

Neurogenesis

Neurogenesis (the formation of new nerve cells in the adult brain) is really part of the larger story about brain plasticity. Neurogenesis reflects the amazing resilience and plasticity of our brains. Expanding upon observations initially made years ago about birds, it has become clear that certain parts of the human brain are capable of generating new neurons throughout life, even during old age.  Not all regions of the brain appear to have this ability to grow new nerve cells, but two regions, the dentate gyrus of the hippocampus and the areas near the lateral ventricles in the olfactory system (which is involved in the sense of smell), are really good at it. The dentate gyrus plays a key role in the function of the hippocampus, the region that is so critical for memory processing. A thousand or more new neurons are born in this region each day and can be incorporated into the circuitry of the hippocampus where they help enhance certain types of learning. These new neurons may be particularly important for processing new information.